Research and science supports Marodyne LIV

How to enhance muscle and bone health

Message from Dr. Clinton Rubin

dr. clinton rubin

I have spent the entire 30 years of my scientific career trying to understand how mechanical signals influence the musculoskeletal system. One of our key findings has been that extremely low magnitude mechanical signals, delivered in the form of LIV (Low Intensity Vibration), have the capacity to dictate the regeneration patterns of mesenchymal stem cells (MSCs) found within the bone marrow to stimulate the formation of bone and muscle and suppress the formation of fat.

We have discovered, through our many years of scientific research in preclinical and clinical studies, that low intensity vibration promotes bone quantity and quality, builds lean muscle mass and the conditioning of muscle reflexes. It is the goal of all biomedical scientists to see the work that we do in the laboratory translate to the clinic, to help the health and well-being of patients. It is very exciting, indeed, that we are finally achieving this goal. Thank you for considering the Marodyne LIV technology as a potential means of restoring and protecting bone and muscle health. It has been a long scientific journey, but we are very, very pleased to see the application of this technology become a reality.

Best Regards

Clinton Rubin

Benefits of using LIV Vibration treatment

LIV - Low Intensity Vibration - works at the same level as the body’s natural physical cell activity and, therefore, allows a way to non-invasively control the actions of cells. In diseases such as osteoporosis, where the normal mobility is endangered or lost due to the weakened bone, LIV treatment is effective because, in essence, it mimics this natural mechanical component and stimulates the body’s natural responses to the biophysical stimuli to build new bone. According to more than 25 years of research, LIV treatment acts as a safe intervention against musculoskeletal collapse. A healthy musculoskeletal system is essential to a healthy ageing process.

How can one signal be effective against several diseases?

Our research is based on how cells respond to low-intensity vibration. While a 0.3g acceleration does not feel like much to an individual, it is a strong signal to an individual cell. Mesenchymal stem cells (MSCs) in adults are found in the bone marrow: these special cells are able to form into various different cell types, including bone cells (osteoblasts), fat cells (adipocytes), collagen cells (fibroblasts), cartilage cells (chondrocytes), and muscle cells (myocytes). Studies show the therapeutic potential of mesenchymal stem cells has increased significantly in recent years. As low intensity vibration signals activate the MSCs, its therapeutic benefit is greatly enhanced due to the potential of these cells. 

25 Years of Research

Over the past 25 years, research focused on Low Intensity Vibration treatment has been funded by the National Institutes of Health (NIH), the National Aeronautics and Space Administration (NASA) and the National Science Foundation (NSF). Researchers have worked to identify those mechanical factors arising from exercise that can stimulate biological tissues such as muscle and bone. This research has shown that low-magnitude mechanical signals (such as Low Intensity Vibration) can build bone and muscle if applied at a high frequency (15 to 90 Hz). To be considered "low magnitude" or "low-intensity", signals should be less than 1.0g in force. One-g is equivalent to Earth’s gravitational field: 9.81 meters per second per second. Similar to exercise, Low Intensity Vibration training is able to exert beneficial effects on many of our body’s physiological systems. Researchers have extensively studied how such small vibrations are able to benefit the body. The research team has established the effectiveness of a Low Intensity Vibration therapy to promote and maintain a healthy musculoskeletal system. It has shown, without doubt, that low intensity vibration promotes the development of mesenchymal stem cells into tissues, such as bone and muscle, while reducing the percentage of cells that develop into fat tissue.

Is Low Intensity Vibration right for you?

Marodyne LIV - Low Intensity Vibration - may be helpful for individuals suffering from the following conditions:

  • Osteoporosis – Bones becoming porous or brittle, due to hormonal changes or age
  • Osteopenia – Bone density levels are lower than normal
  • Sarcopenia – The loss of skeletal muscle and strength
  • Diabetes – A metabolic disorder in which a person has high blood sugar
  • Obesity – The accumulation of excess body fat
  • Back pain

Not just a matter of magnitude

There are fundamental differences between Low Intensity Vibration (LIV) and High Intensity Vibration, more commonly known as Whole Body Vibration (WBV). According to research focused on low intensity vibration, there is a small therapeutic window where mechanical signals are effective without putting you at risk. The delivered signal has to be just right: too little or too much stimulus are both equally ineffective as therapies. In fact, too much signal - as found in whole body vibration devices - can be dangerous for some people, a point which has been emphasised in biomedical literature.

Scientific direction

Solid, scientific experience and substantiated results

The Marodyne LIV product draws on a solid, medical foundation. Known globally as the only provider of a fully medically certified (under the EU Medical Devices Directive), safe Low Intensity Vibration (LIV) platform, Marodyne is supervised by a scientific advisory board with leading experts from the fields of biomedicine, orthopaedics, osteoporosis, metabolism, rehabilitation medicine and stem cell research. The starting points for the development of the treatment were orthopaedics, osteoporosis and space medicine: the future of the research is increasingly determined by new studies and findings from the field of stem cell biology.

Prof. Dr. Clinton Rubin

clint rubin stony brook

Professor Rubin serves as the Chief Scientific Officer at Marodyne LIV. He is also SUNY Distinguished Professor and Chair of the Department of Biomedical Engineering at the State University of New York at Stony Brook, and Director of the NYSTAR Center for Advanced Technology in Medical Biotechnology.

stony brook university new york

His work is targeted towards understanding the cellular mechanisms responsible for the growth, healing and homeostasis of musculoskeletal tissues such as bone, cartilage, tendon, ligament and muscle, as well as the formation of adiposity (fat). [Remark: Homeostasis can be defined as a property of an organism or system that helps it maintain its parameters within a normal range of values - it is key to life] More specifically, this work focuses on how biomechanical stimuli mediate these responses through the control of mesenchymal stem cell differentiation and proliferation. The clinical significance of this work is applicable to the inhibition and reversal of loss of bone mass and bone density, osteopenia and osteoporosis, the promotion of bony ingrowth into implants, the acceleration of fracture healing, and the suppression of obesity and diabetes. Professor Rubin has published over 200 peer-reviewed papers and 50 book chapters on the use of physical stimuli in controlling physiologic processes and the musculoskeletal system.

Professor Rubin is a fellow of the American Institute of Biological and Medical Engineers and a recipient of the Presidential Young Investigator Award from the National Science Foundation, two Kappa Delta Awards from the American Academy of Orthopaedic Surgeons, the John Charnley Award from the Hip Society, the Fuller Albright Award from the American Society of Bone and Mineral Research and the Giovanni Borelli Award from the American Society of Biomechanics.

vibrationstraining wissenschaftliche grundlagen

He is currently funded by National Institutes of Health, National Aeronautics and Space Administration, private industry and the New York Office of Science, Technology and Academic Research. Professor Rubin holds 22 patents, with 14 pending, in the areas of wound repair, stem cell regulation and treatment of bone disease.

Professor Rubin’s research into non-invasive, non-pharmacological intervention to control osteoporosis was referenced in National Geographic’s January 2001 article about surviving space travel. His studies show that the application of extremely low level strains will increase bone formation, and thus may represent the much sought-after "anabolic" stimulus in bone.