Our studies - written by scientists for scientists
Our studies - written by scientists for scientists – have been published in high-calibre medical and scientific journals. Describing in detail the treatment with Marodyne LIV, these reports clearly explain the results and are supported by the findings of extensive research. This meets one of Marodyne’s key principles of ensuring 'evidence-based medicine' is a standard in research.
The development of our treatment was driven jointly by leading medical practitioners, the American space authority NASA and the IOF (International Osteoporosis Foundation) under the leadership of Professor Clinton Rubin. More than one hundred scientific articles have been published with over thirty of these in peer-reviewed journals. A number of double-blind studies have also been published. In these types of study neither the investigators nor the people taking part know who is using the actual device and who is simply using a clever copy that isn’t actually delivering the treatment. Results from double-blind studies are acknowledged to show, beyond doubt, if a treatment works. In the case of Marodyne they show clearly that our LIV treatment significantly supports muscle build-up and better bone quality.
Anabolism: Low mechanical signals strengthen long bones.
Clinton Rubin, A. Simon Turner, Steven Bain, Craig Mallinckrodt & Kenneth McLeod
[2001 Rubin - Anabolism] Although the skeleton's adaptability to load-bearing has been recognized for over a century, the specific mechanical components responsible for strengthening it have not been identified. Here we show that after mechanically stimulating the hindlimbs of adult sheep on a daily basis for a year with 20-minute bursts of very-low-magnitude, high-frequency vibration, the density of the spongy (trabecular) bone in the proximal femur is significantly increased (by 34.2%) compared to controls. As the strain levels generated by this treatment are three orders of magnitude below those that damage bone tissue, this anabolic, non-invasive stimulus may have potential for treating skeletal conditions such as osteoporosis... » read more
Prevention of Postmenopausal Bone Loss by a Low-Magnitude, High-Frequency Mechanical Stimuli: A Clinical Trial Assessing Compliance, Efficacy, and Safety.
Clinton Rubin, Robert Recker, Diane Cullen, John Ryaby, Joan McCabe, and Kenneth McLeod
[2004 Rubin - Postmenopausal Bone Loss] A 1-year prospective, randomized, double-blind, and placebo-controlled trial of 70 postmenopausal women demonstrated that brief periods (<20 minutes) of a low-level (0.2g, 30 Hz) vibration applied during quiet standing can effectively inhibit bone loss in the spine and femur, with efficacy increasing significantly with greater compliance, particularly in those subjects with lower body mass. Introduction: Indicative of the anabolic potential of mechanical stimuli, animal models have demonstrated that short periods (<30 minutes) of low-magnitude vibration (<0.3g)... » read more
Vibration therapy: clinical applications in bone
[2014 J. Rubin - Vibration Therapy] The musculoskeletal system is largely regulated through dynamic physical activity and is compromised by cessation of physical loading. There is a need to recreate the anabolic effects of loading on the musculoskeletal system, especially in frail individuals who cannot exercise. Vibration therapy is designed to be a nonpharmacological analogue of physical activity, with an intention to promote bone and muscle strength... » more
Mechanical signals as anabolic agents in bone.
Engin Ozcivici, Yen Kim Luu, Ben Adler, Yi-Xian Qin, Janet Rubin, Stefan Judex and Clinton T. Rubin
[2010 Ozcivici - anabolic agents] Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease muscle mass and strength, and undermine postural stability, culminating in an elevated risk of skeletal fracture. Concurrently, a marked reduction in the available bone-marrow-derived population of mesenchymal stem cells (MSCs) jeopardizes the regenerative potential that is critical to recovery from musculoskeletal injury and disease. A potential way to combat the deterioration involves harnessing the sensitivity of bone to mechanical signals, which is crucial in defining, maintaining and recovering bone mass... » read more
Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signals
Jesse Muir, Stefan Judex, Yi-Xian Qin, Clinton Rubin
[2011 Muir - Postural instability] Loss of postural stability, as exacerbated by chronic bed rest, aging, neuromuscular injury or disease, results in a marked increase in the risk of falls, potentiating severe injury and even death. To investigate the capacity of low magnitude mechanical signals (LMMS) to retain postural stability under conditions conducive to its decline... » read more
Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults
Jesse Muir, Ph.D., Douglas P. Kiel, M.D., M.P.H, and Clinton T. Rubin, Ph.D.
[2013 Muir - Safety and severity] Whole Body Vibration (WBV) devices are used as a means to augment training, and their potential to treat a range of musculoskeletal diseases and injuries is now being considered. The goal of this work is to determine the degree to which acceleration delivered by WBV devices at the plantar surfaces of a standing human is transmitted through the axial and appendicular skeleton, and how this mechanical challenge corresponds to the safety Threshold Limit Values (TLV) established by the International Standards Organization ISO-2631... » read more
Low-Magnitude High-Frequency Mechanical Signals Accelerate and Augment Endochondral Bone Repair: Preliminary Evidence of Efficacy.
Allen E. Goodship, Timothy J. Lawes, and Clinton T. Rubin.
[2009 Goodship - Bone repair] Fracture healing can be enhanced by load bearing, but the specific components of the mechanical environment which can augment or accelerate the process remain unknown. The ability of low-magnitude, high-frequency mechanical signals, anabolic in bone tissue, are evaluated here for their ability to influence fracture healing. The potential for short duration (17 min), extremely low-magnitude (25 μm), high-frequency (30 Hz) interfragmentary displacements... » read more
Low-Level Vibrations Retain Bone Marrow's Osteogenic Potential and Augment Recovery of Trabecular Bone during Reambulation.
Engin Ozcivici, Yen K. Luu, Clinton T. Rubin, Stefan Judex
[2010 Ozcivici - Osteogenic Potential] Mechanical disuse will bias bone marrow stromal cells towards adipogenesis, ultimately compromising the regenerative capacity of the stem cell pool and impeding the rapid and full recovery of bone morphology. Here, it was tested whether brief daily exposure to high-frequency, low-magnitude vibrations can preserve the marrow environment during disuse and enhance the initiation of tissue recovery upon reambulation.... » read more
Low-Level, High-Frequency Mechanical Signals Enhance Musculoskeletal Development of Young Women With Low BMD.
Vicente Gilsanz, Tishya AL Wren, Monique Sanchez, Frederick Dorey, Stefan Judex, and Clinton Rubin
[2006 Gilsanz - Musculoskeletal Development] The potential for brief periods of low-magnitude, high-frequency mechanical signals to enhance the
musculoskeletal system was evaluated in young women with low BMD. Twelve months of this noninvasive signal, induced as whole body vibration for at least 2 minutes each day, increased bone and muscle mass in the axial skeleton and lower extremities compared with controls. Introduction: The incidence of osteoporosis, a disease that manifests in the elderly, may be reduced by increasing peak bone mass in the young. Preliminary data indicate that extremely low-level mechanical signals are anabolic to bone tissue, and their ability to enhance bone and muscle mass... » read more